Category Archives: Hepatitis

Retransplantation is the only therapeutic option to achieve long-term survival in patients with decompensated HCV cirrhosis after LT. Retransplantation for this indication ranges from 3.6% to 44%. Patient and graft survival rates after retransplantation are inferior to those after primary … Continue reading →

The clinical spectrum of AEs is similar to the non-transplant setting. Dose reductions are frequent and drug discontinuation rates are higher than in nontransplant patients. A major limitation of antiviral therapy is tolerability,particularly with respect to the hematologic AEs of … Continue reading →

The progression of fibrosis and other HCV-associated histopathologic changes may also be related to coagulationcascade activity and hepatic accumulation of iron, which have been associated with mutations in factor V and hemochromatosis genes, respectively. The HIV-HCV coinfection is a particularly … Continue reading →

The results are less certain in patients with a thick chest wall, hepatic congestion of cardiac origin and acute exacerbations of hepatitis. However, it has improved the ability to define the extent of fibrosis without a LB, particularly when combined … Continue reading →

CHC may progress to cirrhosis (in approximately 20% of patients, with a mean duration of 20 years) and subsequently, decompensation and complications, including HCC, develop in about 30% of cases over a period of approximately 4 years (DiBisceglie 2008). Histologically … Continue reading →

Real-time PCR tests are faster and more cost-effective methods that detect very low VL (10-15 IU/ml). Realtime PCR can accurately quantify HCV RNA levels over a linear range exceeding 6 logs (10 IU/mL to 100 million IU/mL). Therefore, a single … Continue reading →

Basic knowledge Hepatitis C may be clinically silent for years and many people have been infected with hepatitis C virus (HCV) for decades without knowing it. Effective screening should focus on populations at-risk for HCV infection. Hepatitis C is diagnosed … Continue reading →